zebrafish heart development & regeneration

Cardiovascular diseases represent the number one cause of morbidity and mortality worldwide, affecting a broad spectrum of ages from babies that are born with congenital heart defects to adults that suffer acute myocardial infarctions and/or develop congestive heart failure over time. Our research program is motivated by the simple assumption that we can use the zebrafish as a model organism to understand how the cardiovascular system is established during development and how it efficiently regenerates following injury during adulthood.Specifically, we are: (1) creating zebrafish models of CHDs to implicate human genetic variants as causal for disease pathogenesis and to uncover mechanism of action, and (2) identifying critical factors regulating cardiomyocyte proliferation with the long-term goal of coaxing human hearts towards regeneration instead of scarring. 

Lab News...

June 27, 2022

Welcome to our high school summer interns representing The Rivers School and Newton North! 

IMG_0062.jpeg
IMG_0061.jpeg
IMG_0060.jpeg

February 6, 2022

Congratulations to Hakan Coskun for

his photograph being selected for display in

the new

Hale

Building

at

Boston

Children's

Hospital. 

hakan coskun_2022[1].jpg
Sandeep Basu_Burns Lab Photo-1.jpg

February 6, 2022

Congratulations to Maryline Abrial and Sandeep Basu for

their new

manuscript

describing

a zebrafish

model of

thoracic aortic root

aneurysm. Sandeep will also be featured in a "First Person" interview.