Heart Function and Cardiomyopathy
The following projects are currently underway or available to pursue in our laboratory:
RNA binding proteins regulating heart function: We are generating and characterizing zebrafish with mutations in RBPMS2, a highly conserved RNA binding protein that we demonstrate is critical for heart function. In addition to pursuing the zebrafish model, we have also created a human iPSC model that phenocopies the zebrafish.
Fetal Alcohol Spectrum Disorder: We have generated and are characterizing a zebrafish model of embryonic alcohol exposure that leads to CHD phenotypes during embryogenesis and heart problems during adulthood. We are pursuing the molecular mechanisms underlying these phenotypes.