The Burns Lab
Publications
Akerberg AA^, Trembley M, Butty V, Schwertner A, Zhao L, Beerens M, Liu X, Mahamdeh M, Yuan S, Boyer L, MacRae C, Nguyen C, Pu WT, Burns CE*, Burns CG*. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circ Res. 2022. 131:980-1000.
^ co-first authors; * co-corresponding authors. PDF
Huang M^, Akerberg AA^, Zhang X, Yoon H, Joshi S, Hallinan C, Nguyen C, Pu WT, Haigis MC, Burns CG*, Burns CE*. Intrinsic myocardial defects underlie an Rbfox deficient zebrafish model of hypoplastic left heart syndrome. Nat Commun 2022. 13: 5877. ^ co-first authors; * co-corresponding authors. PDF
Abrial M^, Basu S^, Huang M, Butty V, Schwertner A, Jeffrey S, Jordan D, Burns CE*, Burns CG*. Latent TGFb binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilation. Disease Models & Mech. 2022. 15(3). ^ co-first authors; * co-corresponding authors PDF
Basu S - First Person Interview. Disease Models & Mech. 2022. 15(3). PDF
Sharpe M^, González-Rosa JM^, Wranitz F, Jeffrey S, Copenhaver K, Burns CG*, Burns CE*. Ruvbl2 suppresses cardiomyocyte proliferation during zebrafish heart development and regeneration. Front Cell Dev. Biol., 2022, 10:800594. ^ co-first authors; * co-corresponding authors PDF
Yin HM, Burns CG*, Burns CE*. Innate Mechanisms of Heart Regeneration. Cold Spring Harb Perspec Biol 2021. a040766. PDF
Burns CG*, Burns CE*. Wnt signaling sets the pace. Developmental Cell 2019. 50(6): 675-676. *co-corresponding authors. PDF
Akerberg AA, Burns CE*, Burns CG*, Nguyen C*. Deep learning enables automated volumetric assessments of cardiac function in zebrafish. Disease Models & Mech. 2019. 12(10): *co-corresponding authors. PDF
Akerberg AA - First Person Interview. Disease Models & Mech. 2019. 12(10). PDF
Ben-Yair R, Butty V, Busby M, Qiu Y, Levine SS, Goren A*, Boyer LA*, Burns CG*, Burns CE*. H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Development. 2019. 146(19):1-10. *co-corresponding authors. PDF
Akerberg AA, Burns CE, Burns CG. Exploring the activities of RBPMS proteins in myocardial biology. Pediatric Cardiology 2019. 1-9. PDF
Galvez-Santisteban M, Chen D, Zhang R, Serrano R, Nguyen C, Zhao L, Nerb L, MasutaniEM, Vermot J, Burns CG, Burns CE, Del Alamo JC, Chi NC. Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLife. 2019. 25(8): 44816. PDF
Zhao L, Ben-Yair R, Burns CE*, Burns CG*. Endocardial Notch signaling promotes cardiomyocyte proliferation in the regenerating
zebrafish heart through Wnt pathway antagonism. Cell Reports. 2019. 26(3): 546-554. *co-corresponding authors PDF
Guner-Ataman B, Gonzalez-Rosa JM, Shah HN, Butty VL, Jeffrey S, Abrial M, Boyer LA, Burns CG*, Burns CE*. Failed progenitor specification underlies the cardiopharyngeal phenotypes in a zebrafish model of 22q11 deletion syndrome. Cell Reports. 2018. 24(5): 1342-1354. * co-corresponding authors. PDF
Gonzalez-Rosa JM, Sharpe M, Field D, Soonpaa MH, Field LJ, Burns CE*, Burns CG*. Myocardial polyploidization creates a barrier to heart regeneration in zebrafish. Developmental Cell. 2018. 44(4): 433-446. *co-corresponding authors. PDF
Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho, NN, Gerard NP, Gerard CJ, Macrae CA, Burns CE, Burns CG, Whited JL, Lee RT. Complement receptor C5aR1 plays an evolutionarily conserved role in successful cardiac regeneration. Circulation 2018; 137:2152-2165. PDF
Paffett-Lugassy N^, Novikov N^, Jeffrey S, Abrial M, Guner-Ataman B, Sakthivel S, Burns CE*, Burns CG*. Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field. Development. 2017. 144: 4616-4624. ^ co-first authors; * co-corresponding authors. PDF
Gonzalez-Rosa JM, Burns CE, Burns CG. Zebrafish heart regeneration: 15 years of discoveries. Regeneration. 2017. 4(3):105-123. PDF
Abrial M^, Paffett-Lugassy N^, Jeffrey S, Jordan D, O’Loughlin E, Frederick CJ, Burns CG*, Burns CE*. TGF-b Signaling is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation. Cell Reports. 2017. 20: 973-983. ^ co-first authors; * co-corresponding authors
Manalo T, May A, Quinn J, Lafontant DS, Shifatu O, He W, Gonzalez-Rosa JM, Burns CG, Burns CE, Burns AR, Lafontant PJ. Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio and Zebrafish Hearts. J Histochem Cytochem. 2016. 64(11): 687-714. PDF
Han P, Bloomekatz J, Ren J, Zhang R, Grinstein JD, Zhao L, Burns CG, Burns CE, Anderson RM, Chi NC. Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 2016; 534:700-704. PDF
Jahangiri L, Sharpe M, Novikov N, Gonzalez Rosa JM, Borikova A, Nevis K, Paffett-Lugassy N, Zhao L, Adams M, Guner-Ataman B, Burns CE*, Burns CG*. The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Development. 2016. 143:113-122. *co-corresponding authors. PDF
Mosimann C*, Panakova D*, Lawson K, Davidson AJ, Musso G, Werdich A, DiBiase A, Nevis K, Zhou Y, Burger A, Carr LA, Khaled Sabeh M, Burns CE, Burns CG, MacRae CA, Zon LI. Chamber identity programs drive early functional partitioning of the heart. Nature Communications. 2015. 6:8146. *co-first authors. PDF
Mahmoud AI*, O’Meara CC*, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi W, Egnaczyk GF, Burns CG, Burns CE, MacRae CA, Poss KD, Lee RT. Nerves regulate cardiomyocyte proliferation and heart regeneration. Developmental Cell. 2015 34(4):387-99.
*co-first authors. PDF
Jang, IH, Lu, Y-F, Zhao, L, Wenzel, PL, Kume, T, Datta, SM, Arora, N, Guiu, J, Lagha, M, Kim, PG, Do, EK, Kim, JH, Schlaeger, TM, Zon, LI, Bigas, A, Burns, CE*, Daley, GQ*. Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. (2015) 125(9):1418-26. PDF
Harrison MR, Bussmann J, Huang Y, Zhao L, Osorio A, Burns CG, Burns CE, Sucov HM, Siekmann AF and Lien CL. Chemokine guided angiogenesis directs coronary vasculature formation in zebrafish. Developmental Cell. 2015. 33(4):442-54. PDF
Burns CG* and Burns CE*. A Crowning Achievement for Deciphering Coronary Origins. Science. (2014) 345: 28-29. PDF
Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, MacRae CA, Lee RT, Burns CG*, Burns CE*. Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proc. Natl. Acad. Sci. USA. 2014. 111:1403-8. * co-corresponding authors. PDF
Paffett-Lugassy N, Singh R, Nevis KR, Guner-Ataman B, O'Loughlin E, Jahangiri L, Harvey RP, Burns CG*, Burns CE*. Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis. Nat Cell Biol. 2013; 15:1362-9. * co-corresponding authors. PDF
Nevis KR, Obregon P, Walsh C, Guner-Ataman B, Burns, CG*, Burns CE*. Tbx1 is required for second heart field proliferation in zebrafish. Developmental Dynamics. 2013; 242:540-9. * co-corresponding authors. PDF
Guner-Ataman B, Paffett-Lugassy N, Adams MA, Nevis KR, Jahangiri L, Obregon P, Kikuchi K, Poss KD, Burns CE*, Burns CG*. Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. Development. 2013; 40:1353-1363. * co-corresponding authors. PDF
Zhou Y, Cashman TJ, Nevis KR, Obregon P, Carney SA, Liu Y, Gu A, Mosimann C, Sondalle S, Peterson RE, Heideman W, Burns CE*, Burns CG*. Latent TGFb binding protein 3 identifies a second heart field in zebrafish. Nature. 2011; 474:645-8. *co-corresponding authors. PDF
Deacon DC, Nevis KR, Cashman TJ, Zhou Y, Zhao L, Washko D, Guner-Ataman B, Burns CG*, Burns CE*. The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis. Development. 2010; 137:1887-96. * co-corresponding authors. PDF